Penis Enlargement Research

[penismith]

Hi,
I am new here. Is anyone else using the name penismith?
I am a biochemistry undergrad in the bay area. Does anyone here know of any penis enlargement research, either academic or corporate, going on in the bay area or anywhere else? I am having a lot of trouble finding such research, does anyone have any ideas on how I might find a lab. Google has not been very helpful.
The prospect of discovering a way to enlarge my penis is what prompted me to take college level biology courses in the first place. I have visited this and similar sites off and on for several years now and the results that many of you get are very encouraging. Unfortunately, between school and work, I have never been able to put in enough time to realize permanent results and I don't anticipate being able to achieve the results I am hoping for through mechanical means alone. My goal right now is to find a lab that is researching penis enlargement. I would love to hear from anyone who has any ideas on how the penis may be enlarged though biochemistry or pharmacology.
I know that the first impulse many of you will feel will be to tell me that I should not let my desire for a larger penis direct my life. I agree with you. That being said, I love biochemistry and I will not consider my life a failure if I am unsuccessful in enlarging my penis.
Many of you will also reflect on the fact that there are life-threatening diseases that deserve the attention and resources of the academic and corporate comminutes. I could not agree with you more. Those of you who study science will know that a development in one area, like PE could very well lend insights or even direct technological solutions to SERIOUS problems.

I am sorry this is so long.
Penismith

Welcome to this forum.

We have had a discussion regarding biochemical PE possibilities. Here is the thread. pub14.ezboard.com/fpeforu...1487.topic (http://pub14.ezboard.com/fpeforumsgeneraldiscussion.showMessage?topicID=148 7.topic)
Maybe you might have some ideas. Good luck in your endeavors.

HnS

[penismith]

Thank you for your reply HardNSoul.
I read the posts on the link you added. Good problem solving discussion. Although I am certainly no expert, I would be careful with collagen degradative enzymes. I looked up collagen and found scurvy. "In the absence of vitamin C, newly synthesized collagen cannot form fibers properly, resulting in skin lesions, fragile blood vessels, poor wound healing."(p135, Fundamentals of Biochemistry, authors: Voet, Voet & Prat)
I am considering insertion of stem cells into the penis along with growth factors of select cell types. These factors would be applied locally in the form of a cream perhaps and would be chemically modified so that the molecule contained an ester bond, which would make its life short in the body to minimize risk of causing problems with other cells in the body. I know I am getting a little technical but I suspect that there are people here with enough education to point out why my idea won’t work if it is flawed. That is what I want.
Thanks,
Penismith

[Big10]

I am interested in the second phase of human testing
(if first phase shows promise!) and of course after
the animal testing phases. Sounds like it might work!
Has anyone every done HGH injections directly?
I used to think that would do the trick.

[penismith]

Thanks BigBob,
HGH might work if one were to use the human genome sequence, which should be in the public domain before too long, to synthesize HGH receptor proteins. If HGH affects penis size (I haven’t had endocrinology yet) then I would not be surprised if we stopped producing receptors for it in penile tissue cell(S) at the end of puberty. My thought is that the cell would be infected with virus casings filled with the proteins mRNA which would direct the cell to produce these receptors. But you really only want the target cells producing these receptors and I don't know how that would be accomplished. Sounds like a great idea. Again, if I don't know what the hell I am talking about, tell me, I am here to learn.
I see you have some knowledge of Pharmacology or the FDA. Are you familiar with any pharmaceutical companies doing PE research or any thoughts on how I might search one out?
Penismith

[penismith]

www.ncbi.nlm.nih.gov/htbi...b=m&Dopt=r (http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10962334&form=6&db=m&Dopt=r)


Some of you will find this interesting.

Penismith

[Kiwi]

Guys, I have the full version of this article if you want me to upload it somewhere, it's short. The guy involved ended up with a girth of around 7.5", but length was not commented on. There are also references to other similar articles. Seems to support the theory that expanding the corpora cavernosa (ie: jelqing) can increase girth. My thoughts are that length is more related to stretching the ligs.

[titanium30]

Interesting case. I have to wonder why a penis gets so hard. Although blood flows in and little leaves during an erection, it seems that the hardness cannot be accounted for by blood flow alone, as arteries having full blood pressure are not as ridid. I'm wondering if the base of the penis does not use it's musculature in a pumping action during the minor spasm that occur during excitement to force more blood into the corpora cavernosa so as to fill it to rigid capacity and that it's slightly elastic nature keeps it rigid at that pressure of the last spasm until excitment is over and the outflow increases. Don't you notice that a PC contraction not only hardens the penis during a contraction (like a hand or base squeeze) but that the penis is harder even after the pc squeeze? I could be wrong on this observation. The "hydraulic" mechanism of valves responsible for the erection I am sure are contained in the penis root beneath the scrotum, nearest the prostate.

Nice to hear that the fellow that experienced priapism didn't lose sexual function. Do priapisms from overdose of erection inducing injections ever result in penis enlargment?

titanium

[wx]

i find this really interesting. thanks, penismith.

actually, there's 3 things i find intersting:

1. they described the corpora cavernosa as hypoxic. i wonder how this fits, if at all, in the cause/effect seqence of disease and/or enlargement?

2. the hypothesis is that the size increase resulted from a permananent loss of elasticity in the tunica. this would seem to indicate there's no new tissue being created, and hence there is an upper limit to size increases. it seems as though a simple microscopic analysis of the tunica could confirm or deny this hypothesis.

3. that must've been one crazy priapism.


kiwi:
i'd be interested in reading the whole thing, if you can upload it or post it somewhere. actually, i have space for posting pe stuff, if you don't. if you email it to me at wx__@hotmail.com i'll put it up.


wx

[titanium30]

I would think that the hypoxic state was simply a side effect of the lack of blood flow. It seems to indicate that it takes a fairly long period of hypoxia before damage occurs to penis tisssue. This is a good thing. I would hope that the penis tissue would have evolved an adaptation for the low blood flow that occurs during an erection.

I think their statement that the size increase resulted from a permanent loss in elasticity of the tunica is a fancy way of saying it was stretched beyond it's limits of elasticity and was permanently deformed (no offence intended in the use of the word deformed). Most materials like tendons and steel have limits of elasticity beyond which plastic deformation occurs. Like a spring that is compressed beyond it's limits and takes a "set" at a new size. That is what we are all hoping for. I really have doubts about the accuracy of the claims that cells divide during penis enlargment. About the only thing that will form anew is scar tissue. That's ok. Muscular hypertrophy is significant and does not involve cell division, just hypertrophy of the individual cells.

Anyone know where the return blood flow is constricted in a normal erection? I have read there are two factors, smooth muscle contraction and expansion of the corpora. I know there is research on right now to produce a drug that reduces the outflow of blood and that a drug is being tested.

titanium

[Kiwi]

I added the file to my briefcase. You can find it at au.briefcase.yahoo.com/kiwisbrief (http://au.briefcase.yahoo.com/kiwisbrief)

It's a zip file called PE Research Article. Also in there is another article I found a while ago related to PE, but no-one here seemed too interested in it. I recommend reading it also.

[wx]

t30--
i suspect you're right re: cell division. in the past, there's been some pretty lengthy discussions about which it is. on the one hand, it doesn't really matter to me--as long as i can get the gains. on the other hand, if understanding the underlying physiology makes that process easier, then i'm all for it. wonder if that guy would mind if i took a little biopsy?...

kiwi--
cool. thanks. i'll check it out.

wx

[penismith]

www.ncbi.nlm.nih.gov/entr...t=Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8916669&dopt=Abstract)

www.ncbi.nlm.nih.gov/entr...t=Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8579269&dopt=Abstract)

www.ncbi.nlm.nih.gov/entr...t=Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8022007&dopt=Abstract)

www.ncbi.nlm.nih.gov/entr...t=Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8366540&dopt=Abstract)

www.ncbi.nlm.nih.gov/entr...t=Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2363439&dopt=Abstract)




Periphery information.

Kiwi, can you get number five. No abstract is provided. It is the one I find most interesting.
Penismith

[Kiwi]

Penismith,

I can get the fifth (American Journal of Medical Genetics) on paper, but not on-line. Since you're in college also, I'm guessing you can get it through your library. If not, I'll find a copy and either scan it or summarise it for you. I did a quick search on the other articles but couldn't find them. If you find anything else that could be good but you can't find it let me know and I'll try and get it.

[penismith]

Hi Kiwi,
My library does not have number five. That’s what I get for going to a college w/o a med school!
It would be great if you could either summarize it or scan it. Did anyone else find any of the other abstracts interesting? I come across a lot of stuff so let me know what you would like to see.
Penismith

[Alcatraz]

Penismith,

Yea, I find all of this interesting - that's why I'm here!

Questions - what does "hypoxic" mean?
what is "megalophallus"?

I realize megalophallus would roughly translate to Huge Johnson but I figure there's more to it than that.

Kiwi, what program do I use to read that file?

[wx]

alcatraz,

i'll stick my mouth in since i'm here:

hypoxic--inadequate oxygenation (of the blood)

megalophallus--you've got it--that's all there is too it (as far as i know).

as far as reading the file, it's compressed so you'll need something to "unzip" it with--winzip, etc. once it's decompressed ("extracted"), it's just a regular html file inside.

now if i can just make some time to read the files myself...

wx

[Kiwi]

Penismith ~ I'll try and get that article this weekend.

Alcatraz ~ Here's a link to WinZip a program which you can use to open the zipped files, (it's approx 1.2Mb)...

ftp://ftp.simtel.net/pub/simtelnet/cnet/win95/utilities/winzip80.exe

[phat9]

I saw an investigative news documentary on ABC some two years ago aboaut new medical breakthroughs on "impotence." It was a one hour documentary, covering hrbs, eercise, HgH, erection drugs like Viagra, and the "direct injection" muscle relaxer.

Titanium30 very intelligently noted (as did I too) that injections of the muscle relaxer directly into the penis produces long lasting, hard erections in the most impotent of men. It works without fail and in large doses CAN AND DOES PRODUCE PROLONGED PRIAPISM.

[Aside: the inventor of this technique according to the ABC show SHOCKED the medical community at a medical convention in Sweden by demonstrating the drug LIVE on himself, by injecting his own penis in front of hundreds of shocked doctors and urologists. At that time impotence was believed to be mostly psychological, but this intraveneous drug disproved that theory, and that was the beginning of the search for an oral, pill-like solution that culiminated in the discovery of Viagra.]

Back to the question........

The show noted that just a smidgen too much of the drug and an erection could go on 3-4-5 -6 hours to several DAYS. They interviewd two men who experienced priapism for several days, after overdosing to go a long time, and both had become totally IMPOTENT.

THUS THE WARNING: DO NOT O.D. ON THE DRUG TO PROLONG AN ERECTION BEYOND THREE HOURS, OR SUFFER THE CONSEQUENCES OF PERMANENT DYSFUNCTION. They were careful to point out how dose-sensitive this treatment is. It works, however, so long as one can stomach putting a needle in his d*&k, albeit a very microscopic one.

[penismith]

Hi Phat8,
Do you know if you are talking about alprostadil or phentolamine?

Penismith

[Kiwi]

Penismith ~ Sorry it's taken so long for me to get back to you. It looks like I won't be able to get that article afterall (the journal seems to have gone missing). Maybe you can get it some other way, perhaps you could request a copy to be delivered to you library from another college?

Kiwi

[penismith]

Hi Kiwi,

Thank you for looking. I can order it from a nearby school. When I get some free time I will do so and post a summary if it is sufficiently interesting. By the way, what are you studying? I will completely understand if you consider that question to be too private.

Penismith

[wx]

ha, well, it took me a month, but i finally got a chance to read all the abstracts and papers. good stuff. on the less relevant side of things i think my favorite part appears in the followup article: "This obviously deserves further attention and we therefore plan to obtain MR images of a man following penis amputation." ooo, can't wait...

kiwi, i'd be intersted in that article too whenever you get it.

wx

[penismith]

Hi Guys,

I have not read this article yet but the abstract shows that hypertrophy of smooth muscle mass is possible in the corpus w/o sickle cell anemia.

www.ncbi.nlm.nih.gov/entr...t=Abstract (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3669186&dopt=Abstract)

Penismith

[Kiwi]

Penismith,

I'm doing a business degree, like an MBA. I don't have much of a science background, but I find all of the research articles very interesting, so keep up the search and let us know what you find out.